Favorskii Rearrangement

FollowFollowFollow Favorskii Rearrangement The Favorskii rearrangement is the reaction between alpha-halo ketones with at least one alpha-H and a nucleophile in basic conditions to generate carboxylic acids, esters, or amides. General features: 1. The halogen...
Evans-Tishchenko Reaction

Evans-Tishchenko Reaction

FollowFollowFollow Evans-Tishchenko Reaction The Evans–Tishchenko reaction is the diastereoselective reduction of β-hydroxy ketones to the corresponding anti 1,3-diol monoesters. The reaction employs a Lewis acid, often samarium iodide, and an aldehyde....
Eschweiler-Clarke Reaction

Eschweiler-Clarke Reaction

FollowFollowFollow Eschweiler-Clarke Reaction The Eschweiler-Clarke reaction allows the methylation of a primary or secondary amine to the corresponding tertiary amine, using excess formic acid and formaldehyde, avoiding the formation of quaternary ammonium salts....
Eschenmoser-Claisen Rearrangement

Eschenmoser-Claisen Rearrangement

FollowFollowFollow Eschenmoser-Claisen Rearrangement The Eschenmoser-Claisen rearrangement is the reaction in which allylic or benzylic alcohols undergo [3,3]-rearrangement when heated with N,N-dimethylacetamide dimethyl acetal to yield a gamma,delta unsaturated...
Diels-Alder Reaction

Diels-Alder Reaction

FollowFollowFollow Diels-Alder Reaction The Diels–Alder reaction is the [4 + 2] cyclization of a diene and a dienophile (i.e., an alkene) to generate a cyclohexene derivative. The D-A reaction is a concerted, pericyclic reaction that generates two new σ-bonds through...
Dieckmann Condensation

Dieckmann Condensation

FollowFollowFollow Dieckmann Condensation The Dieckmann condensation is the intramolecular reaction between an ester, containing an alpha-hydrogen atom, and another ester to give a beta-keto ester. Basically, an intramolecular Claisen Condensation. General features:...