Curtius Rearrangement

Curtius Rearrangement

FollowFollowFollow Curtius Rearrangement The Curtius rearrangement is the thermal decomposition (pyrolysis) of acyl azides to the corresponding isocyanates. General features: 1. The migration occurs with full retention of configuration at the R-group 2. The isocyanate...
Criegee Oxidation

Criegee Oxidation

FollowFollowFollow Criegee Oxidation The Criegee oxidation is a 1,2-diol (glycol) cleavage reaction in which vicinal diols are oxidized to form ketones and aldehydes using lead tetraacetate. Several oxidizing agents such as HIO4, PIDA, cerium(IV) salts, or silver(I)...
Corey-Kim Oxidation

Corey-Kim Oxidation

FollowFollowFollow Corey-Kim Oxidation The Corey-Kim oxidation is the synthesis of aldehydes and ketones from primary and secondary alcohols using N-chlorosuccinimide (NCS), dimethyl sulfide (DMS), and an organic base (Et3N). General features: 1. The reaction...