Noyori Hydrogenation

Noyori Hydrogenation

FollowFollowFollow Noyori Hydrogenation The Noyori asymmetric hydrogenation allows the enantioselective reduction of ketones with hydrogen gas and catalytic amounts of BINAP-Ru(II) complexes. BINAP is a C2-symmetric chiral ligand that is commercially available in both...
Negishi Coupling

Negishi Coupling

FollowFollowFollow Negishi Coupling The Negishi coupling is the nickel or palladium-catalyzed stereoselective reaction of organozincs and organic halides for the formation of carbon-carbon bonds. Even though, organozincs are more reactive than organostannanes (for the...
Nazarov Cyclization

Nazarov Cyclization

FollowFollowFollow Nazarov Cyclization The Nazarov cyclization is the acid catalyzed ring-closure of divinyl ketones for the synthesis of cyclopentenones. Nazarov Cyclization Reaction Mechanism 1. Coordination of the Lewis acid to the carbonyl group and formation of a...
Mitsunobu Reaction

Mitsunobu Reaction

FollowFollowFollow Mitsunobu Reaction The Mitsunobu reaction allows the conversion of primary and secondary alcohols into different functional groups using triphenylphosphine and an azodicarboxylate. The reaction proceeds with inversion of configuration (SN2). General...
Mannich Reaction

Mannich Reaction

FollowFollowFollow Mannich Reaction The Mannich reaction is the condensation of an aldehyde or ketone with a primary or secondary amine and a non-enolizable aldehyde or ketone to prepare aminoalkylated derivatives. Also, the addition of enolizable carbonyl compounds...
Heck Coupling

Heck Coupling

FollowFollowFollow Heck Coupling The Heck reaction is the cross-coupling between an unsaturated halide or triflate and an alkene in the presence of a base and a palladium catalyst. General features: 1. The reaction conditions tolerate a wide range of functional groups...