by Lluis Llorens | Nov 15, 2022 | Named Reactions
FollowFollowFollow Sandmeyer Reaction The Sandmeyer reaction is the substitution of aryldiazonium salts with halides or pseudohalides. General features: 1. The substrate is usually prepared from arylamines via diazotization. 2. Aryldiazonium halides are not isolated....
by Lluis Llorens | Nov 15, 2022 | Named Reactions
FollowFollowFollow Sakurai Allylation The Sakurai allylation (also known as the Hosomi–Sakurai reaction) allows the reaction between allylsilanes with a wide range of aldehydes and ketones in the presence of a Lewis acid to form the corresponding homoallylic alcohols....
by Lluis Llorens | Nov 15, 2022 | Named Reactions
FollowFollowFollow Saegusa-Ito Oxidation The Saegusa-Ito oxidation allows the regioselective introduction of an alpha, beta C–C double bond to cyclic and acyclic ketones. The reaction involves the formation of a silyl enol ether followed by a Pd-mediated oxidation to...
by Lluis Llorens | Nov 15, 2022 | Named Reactions
FollowFollowFollow Rubottom Oxidation The Rubottom oxidation is the alpha-hydroxylation of carbonyl compounds by the reaction between silyl enol ethers and peroxyacids. Rubottom Oxidation Reaction Mechanism 1. Formation of the silyl enol ether. 2. Oxidation of the...
by Lluis Llorens | Nov 10, 2022 | Named Reactions
FollowFollowFollow Ritter Reaction The Ritter reaction is the acid-induced nucleophilic addition of a nitrile to a carbenium ion to deliver a N-alkyl amide. General features: 1. The reaction is used for the preparation of acyclic amides and heterocycles such as...
by Lluis Llorens | Sep 30, 2022 | Named Reactions
FollowFollowFollow Reimer-Tiemann Reaction The Reimer-Tiemann reaction is the formylation of phenols using chloroform in the presence of a strong base, normally an aqueous hydroxide solution. General features: 1. The reaction is an electrophilic aromatic substitution...
