Cope Elimination

Cope Elimination

The Cope elimination reaction involves the stereoselective syn elimination of tertiary amine oxides, which are typically prepared by the oxidation of tertiary amines with a peroxide. The Cope elimination promotes the intramolecular elimination of an alkyl N-oxide to...
Claisen Rearrangement

Claisen Rearrangement

The Claisen rearrangement is a pericyclic reaction involving a concerted mechanism with a cyclic transition state. Specifically, it belongs to the group of sigmatropic reactions, where one σ-bond is exchanged for another. In the Claisen rearrangement, a...
Chugaev Elimination

Chugaev Elimination

The Chugaev elimination involves the formation of olefins by pyrolysis of the corresponding xanthates derived from β-hydrogen-containing alcohols via syn elimination. The Chugaev elimination reaction is analogous to the thermal decomposition of carboxylic esters of...
Chan-Lam Coupling

Chan-Lam Coupling

The Chan-Lam coupling is the cross-coupling reaction between an aryl boronic acid and an amine or alcohol to generate the corresponding secondary aryl amine or ether. In contrast to other cross-coupling reactions, the Chan-Lam reaction is unique in that it couples two...
Bischler-Napieralski Reaction

Bischler-Napieralski Reaction

The Bischler-Napieralski reaction is an electrophilic aromatic substitution that facilitates the cyclization of β-arylethylamides or β-arylethylcarbamates using a condensing agent such as phosphorus oxychloride (POCl3), phosphorus pentoxide (P2O5), or zinc...
Birch Reduction

Birch Reduction

The Birch reduction involves the 1,4-reduction of aromatic rings to produce unconjugated cyclohexadienes and heterocycles. This transformation is achieved using alkali metals (Na, Li, K) dissolved in liquid ammonia in the presence of an alcohol, which serves as a...