Tsuji-Trost Allylation

Tsuji-Trost Allylation

FollowFollowFollow Tsuji-Trost Allylation The Tsuji-Trost reaction is the palladium-catalyzed allylation of nucleophiles with allylic compounds via π-allylpalladium complexes. General features: 1. The reaction is regioselective. And unsymmetrical allyl substrates...
Tebbe Olefination

Tebbe Olefination

FollowFollowFollow Tebbe Olefination The Tebbe olefination is the one-carbon homologation of carbonyl compounds using the Tebbe reagent. General features: 1. The Tebbe reagent is commercially available, but it can be prepared from the reaction between titanocene...
Takai Olefination

Takai Olefination

FollowFollowFollow Takai Olefination The Takai olefination is the chromium(II)-mediated one-carbon homologation of aldehydes with haloform. General features: 1. The haloform used can be iodoform, bromoform, or chloroform, being iodoform the most reactive and...
Strecker Synthesis

Strecker Synthesis

FollowFollowFollow Strecker Synthesis The Strecker reaction is the condensation of an aldehyde or ketone with a primary amine or ammonia and hydrogen cyanide to afford the corresponding alpha-aminonitrile. General features: 1. The α-amino nitriles are often hydrolyzed...
Stille Coupling

Stille Coupling

FollowFollowFollow Stille Coupling The Stille cross-coupling is the palladium-catalyzed reaction between stannanes and halides to generate a C–C bond. General features: 1. The organotin reagents tolerate a wide variety of functional groups and are not sensitive to...
Staudinger Reaction

Staudinger Reaction

FollowFollowFollow Staudinger Reaction The Staudinger reaction allows the transformation of organic azides into the corresponding aza-ylides by the reaction with triphenylphosphine. Staudinger Reaction Reaction Mechanism 1. Triphenylphosphine reacts with the azide to...