Sonogashira Coupling

Sonogashira Coupling

FollowFollowFollow Sonogashira Coupling The Sonogashira cross-coupling is the copper-palladium catalyzed reaction of terminal alkynes with aryl or vinyl halides. General features: 1. It can be carried out at room temperature. 2. The base can serve as the solvent but a...
Simmons-Smith Reaction

Simmons-Smith Reaction

FollowFollowFollow Simmons-Smith Reaction The Simmons-Smith reaction is a ring-forming reaction that allows the transformation of cyclopropanes by the reaction of alkenes with diiodomethane in the presence of zinc–copper couple. General features: 1. A wide range of...
Shi Epoxidation

Shi Epoxidation

FollowFollowFollow Shi Epoxidation The Shi asymmetric epoxidation allows the synthesis of epoxides from alkenes using a fructose-derived organocatalyst with Oxone. Shi Epoxidation Reaction Mechanism 1. Oxidation of the catalyst with Oxone to generate the active...
Corey-Fuchs Homologation

Corey-Fuchs Homologation

FollowFollowFollow Corey-Fuchs Homologation The Corey-Fuchs reaction is the one-carbon homologation of aldehydes to the corresponding terminal alkynes using carbon tetrabromide and triphenylphosphine. General features: 1. For the transformation of the dibromoolefins...
Corey-Chaykovsky Reactions

Corey-Chaykovsky Reactions

FollowFollowFollow Corey-Chaykovsky Reactions The Corey-Chaykovsky reactions allow the preparation of epoxides from aldehydes or ketones and aziridines from imines using sulfur ylides. Also, alpha,beta-unsaturated carbonyl compounds produce cyclopropane derivatives....
Robinson Annulation

Robinson Annulation

FollowFollowFollow Robinson Annulation The Robinson annulation is a C–C bond-forming reaction for the synthesis of six-membered rings. It combines a Michael addition followed by an aldol condensation. It is used in organic chemistry for ring formation to create 6...