Grieco Elimination

Grieco Elimination

FollowFollowFollow Grieco Elimination The Grieco elimination allows the dehydration of an aliphatic primary alcohol through a selenide intermediate to deliver a terminal alkene. Grieco Elimination Reaction Mechanism 1. The phosphine displaces the cyanide. 2....
Friedel-Crafts Reactions

Friedel-Crafts Reactions

FollowFollowFollow Friedel-Crafts Reactions The Friedel-Crafts Acylation involves the introduction of a keto group into an aromatic or aliphatic substrate by using an acyl halide in the presence of a Lewis acid catalyst. The Friedel-Crafts Alkylation involves the...
Fleming-Tamao Oxidation

Fleming-Tamao Oxidation

FollowFollowFollow Fleming-Tamao Oxidation The Fleming-Tamao oxidation allows the transformation of carbon-silicon bonds to the corresponding carbon-oxygen bonds. General features: 1. Carbon-silicon bonds can be introduced stereospecifically. For example, via the...
Doering-LaFlamme Reaciton

Doering-LaFlamme Reaciton

FollowFollowFollow Doering-LaFlamme Reaction The Doering-LaFlamme allene synthesis is a reaction in organic chemistry that converts alkenes to the corresponding allenes by the insertion of a carbon atom. Doering-LaFlamme Reaction Reaction Mechanism 1. The haloform is...
Corey-Winter Olefination

Corey-Winter Olefination

FollowFollowFollow Corey-Winter Olefination The Corey-Winter olefination allows the stereospecific synthesis of alkenes from 1,2-diols through the formation of a cyclic thiocarbonate. General features: 1. The reaction is completely stereospecific and high-yielding. 2....
Corey-Gilman-Ganem Oxidation

Corey-Gilman-Ganem Oxidation

FollowFollowFollow Corey-Gilman-Ganem Oxidation The Corey-Gilman-Ganem oxidation allows the transformation of benzylic or α,β-unsaturated aldehydes into the corresponding methyl esters. The targeted aldehydes are oxidized to esters in the presence of MnO2 and...