Kumada Coupling

Kumada Coupling

FollowFollowFollow Kumada Coupling The Kumada cross-coupling is the transition metal-catalyzed carbon-carbon bond-forming reaction of alkenyl or aryl halides and organomagnesium or organolithium reagents. General features: 1. The coupling is stereoselective, and the...
Nozaki-Hiyama-Kishi Reaction

Nozaki-Hiyama-Kishi Reaction

FollowFollowFollow Nozaki-Hiyama-Kishi Reaction The Nozaki-Hiyama-Kishi reaction allows the coupling between halides and aldehydes to generate the corresponding alcohols. Nozaki-Hiyama-Kishi Reaction Reaction Mechanism 1. Ni(II) is first reduced to Ni(0) with two...
Ireland-Claisen Rearrangement

Ireland-Claisen Rearrangement

FollowFollowFollow Ireland-Claisen Rearrangement The Ireland-Claisen rearrangement is the [3,3]-sigmatropic rearrangement of a silyl-stabilized enolate (silyl ketene acetal) derivatized from an allylic ester with a strong base to deliver a gamma,delta-unsaturated...
Hofmann Elimination

Hofmann Elimination

FollowFollowFollow Hofmann Elimination The Hofmann elimination is the preparation of alkenes from the treatment of quaternary ammonium salts with silver oxide, water, and heat. General features: The Hofmann elimination is a β-elimination. Thus, the β-hydrogen is...
Hell-Volhard-Zelinsky Reaction

Hell-Volhard-Zelinsky Reaction

FollowFollowFollow Hell-Volhard-Zelinsky Reaction The Hell-Volhard-Zelinsky reaction allows the preparation of alpha-halo carboxylic acids by treating the corresponding acid with an halogen and phosphorous trihalide at high temperatures. General features: 1. The...
Haloform Reaction

Haloform Reaction

FollowFollowFollow Haloform Reaction The Lieben Haloform reaction allows the transformation of methyl ketones into carboxylic acids producing haloform. General features: 1. A way of synthesizing carboxylic acids with one less carbon atom. 2. The reaction is usually...