Prins Reaction

Prins Reaction

FollowFollowFollow Prins Reaction The Prins reaction is the acid-catalyzed condensation of alkenes with aldehydes. The reaction involves the electrophilic addition of an aldehyde to an alkene followed by the capture of a nucleophile or elimination. General features:...
Pinner Reaction

Pinner Reaction

FollowFollowFollow Pinner Reaction The Pinner reaction is the acid-catalyzed reaction of a nitrile with an alcohol to afford an imino ester salt that may undergo nucleophilic addition with a variety of compounds. General features: 1. The reaction is carried out in...
Peterson Olefination

Peterson Olefination

FollowFollowFollow Peterson Olefination The Peterson olefination is the chemical reaction of alpha-silyl carbanions and carbonyl compounds for the preparation of alkenes. It is considered to be the silicon-variant of the Wittig reaction. General features: 1. The...
Pauson-Khand Reaction

Pauson-Khand Reaction

FollowFollowFollow Pauson-Khand Reaction The Pauson-Khand reaction is the transition metal catalyzed formal [2+2+1] cycloaddition of alkynes, alkenes, and carbon-monoxide to form substituted cyclopentenones. General features: 1. The reaction can be inter- and...
Malonic Synthesis

Malonic Synthesis

FollowFollowFollow Malonic Synthesis The Malonic ester synthesis is the alkylation of malonic ester enolates with organic halides followed by thermal decarboxylation of the alkylated products to deliver substituted acetic acid derivatives. General features: 1. The pKa...
Matteson Reactions

Matteson Reactions

FollowFollowFollow Matteson Reactions The Matteson epoxidation allows the preparation of oxiranes from carbonyl compounds and (bromomethyl)lithium. The Matteson homologation allows the conversion of boronic esters by the insertion of methylene into the C–B bond....