Vilsmeier-Haack Reaction

Vilsmeier-Haack Reaction

FollowFollowFollow Vilsmeier-Haack Reaction The Vilsmeier-Haack reaction is the formylation reaction of an electron-rich arene using a Vilsmeier reagent. The reagent is prepared from a N,N-disubstituted formamide (such as DMF) and POCl3. General features: 1. The...
Van Leusen Reaction

Van Leusen Reaction

FollowFollowFollow Van Leusen Reaction The Van Leusen reaction allows the transformation of ketones into nitriles, aldehydes into oxazoles, and aldimines into imidazoles by the reaction of each substrate with tosylmethyl isocyanide (TosMIC). Van Leusen Reaction...
Transesterification Reaction

Transesterification Reaction

FollowFollowFollow Transesterification Reaction The Transesterification reaction is the process of exchanging the alkoxy group of an ester with another alcohol. The reaction is catalyzed by the addition of an acid (which protonates the carbonyl group and makes the...
Stork Enamine Synthesis

Stork Enamine Synthesis

FollowFollowFollow Stork Enamine Synthesis The Stork enamine synthesis involves the alkylation or acylation of an enamine with the corresponding reagent. General features: 1. The preparation of the enamines takes place with one equivalent of a secondary amine. 2....
Skraup Reaction

Skraup Reaction

FollowFollowFollow Skraup Reaction The Skraup synthesis is the reaction between anilines and glycerol in the presence of sulfuric acid and an oxidizing agent to deliver the corresponding quinolines. Skraup Reaction Reaction Mechanism 1. The glycerol is dehydrated to...
Shapiro Olefination

Shapiro Olefination

FollowFollowFollow Shapiro Olefination The Shapiro olefination allows the preparation of alkenes from the corresponding aldehydes or ketones. The reaction involves an intermediate hydrazone, and it is carried out in the presence of 2 equivalents of an organolithium...