Barbier Reaction

Barbier Reaction

by | Mar 29, 2025 | Named Reactions

The Barbier reaction is an organometallic transformation involving the reaction between an alkyl halide, a carbonyl group, and a metal, resulting in the formation of a primary, secondary, or tertiary alcohol. In contrast to the Grignard reaction, the Barbier coupling...
Babler-Dauben Oxidation

Babler-Dauben Oxidation

by | Mar 28, 2025 | Named Reactions

The Babler-Dauben oxidation is the catalytic chromium-mediated 1,3-oxidative transposition of allylic alcohols to give α,β-unsaturated carbonyl compounds. Typical systems include the Jones reagent (CrO3/aq. H2SO4), pyridinium dichromate (PDC) and pyridinium...
Arndt-Eistert Homologation

Arndt-Eistert Homologation

by | Mar 27, 2025 | Named Reactions

The Arndt-Eistert homologation allows the reaction of activated carboxylic acids with diazomethane followed by a Wolff-rearrangement of the diazo ketone intermediate. The reaction generally proceeds with retention of configuration. If the reaction is conducted in the...
Fischer Esterification

Fischer Esterification

by | Mar 26, 2025 | Named Reactions

The Fischer esterification is a reaction between a carboxylic acid and an alcohol in the presence of an acid catalyst to produce the corresponding ester. The Fischer esterification is straightforward. Acidic conditions can be used if acid-sensitive functional groups...
Gabriel Synthesis

Gabriel Synthesis

by | Mar 25, 2025 | Named Reactions

The Gabriel synthesis of amines is the chemical reaction that transforms primary alkyl halides into primary amines in a two-step reaction process. (i) Potassium phthalimide is first alkylated, and (ii) the resulting N- alkylphthalimide is subsequently hydrolyzed. DMF,...
Hofmann Rearrangement

Hofmann Rearrangement

by | Mar 24, 2025 | Named Reactions

The Hofmann rearrangement allows the conversion of primary carboxamides to the corresponding one-carbon shorter amines. There is complete retention of configuration when enantiopure amides are used. The reaction can form a wide range of products, including alkyl and...