Suzuki coupling

Suzuki coupling

by | Mar 21, 2025 | Named Reactions

The Suzuki coupling, or Suzuki–Miyaura reaction, is a palladium-catalyzed cross-coupling between organoboronic acids or esters and organic halides or triflates under basic conditions to form a new C–C sigma bond. The Suzuki coupling reaction is performed between an...
Buchwald-Hartwig coupling

Buchwald-Hartwig coupling

by | Mar 21, 2025 | Named Reactions

The Buchwald-Hartwig coupling is a direct Pd-catalyzed C–N or C–O bond formation reaction between aryl halides and amines or alcohols, typically conducted in the presence of a stoichiometric amount of base. The coupling can be both intermolecular and intramolecular...
Michael Reaction

Michael Reaction

by | Mar 7, 2025 | Named Reactions

The Michael reaction or Michael addition is a C–C bond-forming reaction. It consists of the nucleophilic addition of an activated nucleophile (Michael donor) to an α,β-unsaturated carbonyl compound (Michael acceptor). It belongs to the class of conjugate additions or...
Wolff-Kishner Reduction

Wolff-Kishner Reduction

by | Mar 4, 2025 | Named Reactions

The Wolff-Kishner reduction allows the deoxygenation of aldehydes and ketones to hydrocarbons via the corresponding hydrazones under basic conditions and heat. The reaction is commonly employed to remove a carbonyl group after it has served its synthetic purpose in...
Reimer-Tiemann Reaction

Reimer-Tiemann Reaction

by | Mar 1, 2025 | Named Reactions

The Reimer-Tiemann reaction facilitates the formylation of phenols using chloroform and a strong base, typically an aqueous hydroxide solution. The reaction proceeds via electrophilic aromatic substitution with the formed dichlorocarbene. While the regioselectivity is...
Clemmensen Reduction

Clemmensen Reduction

by | Mar 1, 2025 | Named Reactions

The Clemmensen reduction allows the conversion of a carbonyl group to the corresponding methylene group using zinc amalgam and concentrated hydrochloric acid. Due to its original harsh conditions, the Clemmensen reduction is rarely used in modern organic synthesis....

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