Mukaiyama Hydration

Mukaiyama Hydration

FollowFollowFollow Mukaiyama Hydration The Mukaiyama hydration allows the transformation of an olefin to the corresponding alcohol with Markovnikov selectivity. General features: 1. The use of a silane reductant allows for this reaction to be carried out without heat....
Nicholas Reaction

Nicholas Reaction

FollowFollowFollow Nicholas Reaction The Nicholas reaction allows the conversion of propargylic alcohols to the corresponding substituted alkynes by the reaction with a nucleophile in the presence of dicobalt octacarbonyl and a Lewis acid. Nicholas Reaction Reaction...
Synthesis of Tegoprazan

Synthesis of Tegoprazan

FollowFollowFollow Synthesis of Tegoprazan Chemical synthesis of Tegoprazan, a drug discovered by Pfizer and developed by RaQualia Pharma and CJ Healthcare for the treatment of gastroesophageal reflux disease (GERD). In 2018 its commercial use was approved in Korea....
Synthesis of Avatrombopag

Synthesis of Avatrombopag

FollowFollowFollow Synthesis of Avatrombopag Avatrombopag is a medication approved by the United States Food and Drug Administration (USFDA) and the European Medicine Agency (EMA). The drug acts as a thrombopoietin receptor agonist, and it was indicated for the...
Reduction Reactions

Reduction Reactions

FollowFollowFollow Reduction Reactions This post is about reduction reactions in organic chemistry. These are reactions that change the oxidation state of the atoms on the substrate. Thus, reduction occurs when the oxidation number of an atom becomes smaller. The...