Appel Reaction

Appel Reaction

The Appel reaction allows the conversion of an alcohol into the corresponding alkyl chloride under mild conditions by the reaction of triphenylphosphine and tetrachloromethane with the alcohol. With primary and secondary alcohols, the halide reacts in a SN2 fashion,...
Horner-Wadsworth-Emmons Reaction

Horner-Wadsworth-Emmons Reaction

The Horner-Wadsworth-Emmons (HWE) reaction allows the stereoselective olefination of aldehydes and ketones using stabilized phosphonate carbanions. The reaction favors the formation of (E)-alkenes. The Still-Gennari conditions (see example 2 and example 7) allow the...
Oliceridine

Oliceridine

FollowFollowFollow Oliceridine Oliceridine is an opioid medication that was approved by the FDA for the treatment of moderate to severe acute pain in adults. The medication is indicated for short-term intravenous use in hospitals and other controlled clinical...
Protection of Amines

Protection of Amines

FollowFollowFollow Protection of Amines This post is about reactions involving the protection of amines in organic chemistry. The post is active and growing, so you can expect more examples to be added over time. Please be sure to come back. The updates will be...
Protection of Alcohols

Protection of Alcohols

FollowFollowFollow Protection of Alcohols This post is about reactions involving the protection of alcohols in organic chemistry. The post is active and growing, so you can expect more examples to be added over time. Please be sure to come back. The updates will be...