by Lluis Llorens | Apr 6, 2023 | Named Reactions
FollowFollowFollow Nicholas Reaction The Nicholas reaction allows the conversion of propargylic alcohols to the corresponding substituted alkynes by the reaction with a nucleophile in the presence of dicobalt octacarbonyl and a Lewis acid. Nicholas Reaction Reaction...
by Lluis Llorens | Apr 2, 2023 | Synthesis of Drugs
FollowFollowFollow Synthesis of Tegoprazan Chemical synthesis of Tegoprazan, a drug discovered by Pfizer and developed by RaQualia Pharma and CJ Healthcare for the treatment of gastroesophageal reflux disease (GERD). In 2018 its commercial use was approved in Korea....
by Lluis Llorens | Mar 21, 2023 | Synthesis of Drugs
FollowFollowFollow Synthesis of Avatrombopag Avatrombopag is a medication approved by the United States Food and Drug Administration (USFDA) and the European Medicine Agency (EMA). The drug acts as a thrombopoietin receptor agonist, and it was indicated for the...
by Lluis Llorens | Jan 14, 2023 | Transformations
FollowFollowFollow Reduction Reactions This post is about reduction reactions in organic chemistry. These are reactions that change the oxidation state of the atoms on the substrate. Thus, reduction occurs when the oxidation number of an atom becomes smaller. The...
by Lluis Llorens | Jan 1, 2023 | Transformations
FollowFollowFollow Oxidation Reactions This post is about oxidation reactions in organic chemistry. These are reactions that change the oxidation state of the atoms on the substrate. Thus, oxidation occurs when the oxidation number of an atom becomes larger. The scope...
