Horner-Wadsworth-Emmons Reaction

Horner-Wadsworth-Emmons Reaction

The Horner-Wadsworth-Emmons (HWE) reaction allows the stereoselective olefination of aldehydes and ketones using stabilized phosphonate carbanions. The reaction favors the formation of (E)-alkenes. The Still-Gennari conditions (see example 2 and example 7) allow the...