Arndt-Eistert Homologation

Arndt-Eistert Homologation

by | Mar 27, 2025 | Named Reactions

The Arndt-Eistert homologation allows the reaction of activated carboxylic acids with diazomethane followed by a Wolff-rearrangement of the diazo ketone intermediate. The reaction generally proceeds with retention of configuration. If the reaction is conducted in the...
Wittig Reaction

Wittig Reaction

by | Feb 28, 2025 | Named Reactions

The Wittig reaction involves the formation of C–C double bonds, olefins, from carbonyl compounds and phosphorous ylides. The phosphorous ylides can be prepared from a triaryl- or trialkylphosphine (e.g., triphenylphosphine) and an alkyl halide followed by...
Seyferth-Gilbert Homologation

Seyferth-Gilbert Homologation

by | Nov 15, 2022 | Named Reactions

FollowFollowFollow Seyferth-Gilbert Homologation The Seyferth-Gilbert homologation allows the conversion of carbonyl compounds to the corresponding terminal or internal alkynes with the aid of alpha-diazophosphonates under basic conditions. Seyferth-Gilbert...
Matteson Reactions

Matteson Reactions

by | Sep 29, 2022 | Named Reactions

FollowFollowFollow Matteson Reactions The Matteson epoxidation allows the preparation of oxiranes from carbonyl compounds and (bromomethyl)lithium. The Matteson homologation allows the conversion of boronic esters by the insertion of methylene into the C–B bond....
Doering-LaFlamme Reaciton

Doering-LaFlamme Reaciton

by | Sep 11, 2022 | Named Reactions

FollowFollowFollow Doering-LaFlamme Reaction The Doering-LaFlamme allene synthesis is a reaction in organic chemistry that converts alkenes to the corresponding allenes by the insertion of a carbon atom. Doering-LaFlamme Reaction Reaction Mechanism 1. The haloform is...