Bischler-Napieralski Reaction

Bischler-Napieralski Reaction

The Bischler-Napieralski reaction is an electrophilic aromatic substitution that facilitates the cyclization of β-arylethylamides or β-arylethylcarbamates using a condensing agent such as phosphorus oxychloride (POCl3), phosphorus pentoxide (P2O5), or zinc...
Birch Reduction

Birch Reduction

The Birch reduction involves the 1,4-reduction of aromatic rings to produce unconjugated cyclohexadienes and heterocycles. This transformation is achieved using alkali metals (Na, Li, K) dissolved in liquid ammonia in the presence of an alcohol, which serves as a...
Baylis-Hillman Reaction

Baylis-Hillman Reaction

The Baylis-Hillman reaction, sometimes referred to as the Morita-Baylis-Hillman reaction, is a C–C bond-forming reaction between the α-position of an activated alkene (alkyne) and the carbonyl of an aldehyde. It is usually catalyzed by a tertiary amine such as DABCO...
Barton-McCombie Reaction

Barton-McCombie Reaction

The Barton-McCombie reaction is a deoxygenation reaction in which a hydroxy-functional group in an organic compound is replaced by a hydrogen atom to give an alkyl group. The alcohol is first transformed into a thioxoester that is then exposed to n-Bu3SnH and AIBN in...
Barbier Reaction

Barbier Reaction

The Barbier reaction is an organometallic transformation involving the reaction between an alkyl halide, a carbonyl group, and a metal, resulting in the formation of a primary, secondary, or tertiary alcohol. In contrast to the Grignard reaction, the Barbier coupling...