Chugaev Elimination

Chugaev Elimination

by | Apr 20, 2025 | Named Reactions

The Chugaev elimination involves the formation of olefins by pyrolysis of the corresponding xanthates derived from β-hydrogen-containing alcohols via syn elimination. The Chugaev elimination reaction is analogous to the thermal decomposition of carboxylic esters of...
Chan-Lam Coupling

Chan-Lam Coupling

by | Apr 11, 2025 | Named Reactions

The Chan-Lam coupling is the cross-coupling reaction between an aryl boronic acid and an amine or alcohol to generate the corresponding secondary aryl amine or ether. In contrast to other cross-coupling reactions, the Chan-Lam reaction is unique in that it couples two...
Bischler-Napieralski Reaction

Bischler-Napieralski Reaction

by | Apr 7, 2025 | Named Reactions

The Bischler-Napieralski reaction is an electrophilic aromatic substitution that facilitates the cyclization of β-arylethylamides or β-arylethylcarbamates using a condensing agent such as phosphorus oxychloride (POCl3), phosphorus pentoxide (P2O5), or zinc...
Birch Reduction

Birch Reduction

by | Apr 6, 2025 | Named Reactions

The Birch reduction involves the 1,4-reduction of aromatic rings to produce unconjugated cyclohexadienes and heterocycles. This transformation is achieved using alkali metals (Na, Li, K) dissolved in liquid ammonia in the presence of an alcohol, which serves as a...
Baylis-Hillman Reaction

Baylis-Hillman Reaction

by | Apr 2, 2025 | Named Reactions

The Baylis-Hillman reaction, sometimes referred to as the Morita-Baylis-Hillman reaction, is a C–C bond-forming reaction between the α-position of an activated alkene (alkyne) and the carbonyl of an aldehyde. It is usually catalyzed by a tertiary amine such as DABCO...